Endocrine Abstracts

Radium-223 was associated with high incidence of non-vertebral fractures in patients with castration-resistant prostate cancer (CRPC). The determinants of this effect are unknown and it is still unclear whether Radium-223 may induce skeletal fragility regardless of other therapies of CRPC. We aimed at evaluating the incidence and determinants of vertebral fractures (VFs), i.e. the hallmark of skeletal fragility, in CRCP patients undergoing Radium-223 therapy in the real-life c...

Radioiodine (131I) administration has been found to be effective in the treatment of hyperfunctioning and normofunctioning multinodular goiter. Moreover, lithium therapy has been shown to enhance the radioiodine efficacy and to reduce the transient thyrotoxicosis induced by radioiodine.Aim of the present study was to evaluate the long term efficacy of 131I with or without lithium administration in the treatment of non toxic multinod...